Pancreatic Cancer Detection Consortium Biomarker Bakeoff: A Phase 2 blinded biomarker validation and panel discovery study
The CA19-9/FUT2/3 panel was the best performing panel in this biomarker bakeoff. Its evaluation in larger studies is warranted. Biomarker bakeoffs are an effective strategy for comparing the performance of promising biomarkers for pancreatic cancer early detection, and the PCDC is well poised to conduct such studies. Recommendations for performing such studies are provided.
Authors
- Masataka Hayashi (ORCID: https://orcid.org/0000-0002-1823-0205)
- Grant Izmirlian (ORCID: https://orcid.org/0000-0002-0481-631X)
- S. K. Srivastava (ORCID: https://orcid.org/0000-0001-8237-9189)
- Suyu Liu (ORCID: https://orcid.org/0000-0003-0126-2646)
- William R. Bamlet (ORCID: https://orcid.org/0000-0003-2903-1284)
- Ann M. Killary (ORCID: https://orcid.org/0000-0002-9250-0832)
- Seetharaman Balasenthil
- Ann L. Oberg (ORCID: https://orcid.org/0000-0003-2539-9807)
- Shounak Majumder
- Gopalakrishnan Natarajan (ORCID: https://orcid.org/0000-0001-8813-764X)
- Daniel S. Herman (ORCID: https://orcid.org/0000-0003-2873-587X)
- Brianna M. Krusen (ORCID: https://orcid.org/0009-0006-7197-5843)
- Ken Zaret
- Brian M. Wolpin
- Surinder K. Batra
- Michael G. Goggins
- Maneesh Jain
- Subrata Sen
- Michael A. Hollingsworth
- Lynette M. Smith
Institutions
- Nebraska Medical Center (US)
- Mayo Clinic (US)
- The University of Texas MD Anderson Cancer Center (US)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- Dana-Farber Cancer Institute (US)
- Mayo Clinic in Arizona (US)
- National Cancer Institute (MY)
- National Cancer Institute (US)
- Mayo Clinic in Florida (US)
- University of Nebraska Medical Center (US)
- University of Pennsylvania (US)
- Philadelphia University (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2026-03-23
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-4061
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00