In Silico analysis of CYP2C19 genetic variants and their Impact on Pharmacogenomics

This study provides an in silico analysis of four CYP2C19 genetic variants—rs3758581, rs113994117, rs12248560, and rs28399504—to predict their functional impact on drug metabolism. Using SIFT and PolyPhen-2, the research categorizes these mutations into metabolic phenotypes to improve personalized medicine and safety for drugs like Clopidogrel.

Authors

Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-03-22
DOI
https://doi.org/10.5281/zenodo.19162517
Primary Topic
Antiplatelet Therapy and Cardiovascular Diseases
Type
article
Field-Weighted Citation Impact
0.00
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article

In Silico analysis of CYP2C19 genetic variants and their Impact on Pharmacogenomics

Aakriti Kaushal
Zenodo (CERN European Organization for Nuclear Research)
Antiplatelet Therapy and Cardiovascular Diseases
article

In Silico analysis of CYP2C19 genetic variants and their Impact on Pharmacogenomics

Aakriti Kaushal
article en

Abstract

This study provides an in silico analysis of four CYP2C19 genetic variants—rs3758581, rs113994117, rs12248560, and rs28399504—to predict their functional impact on drug metabolism. Using SIFT and PolyPhen-2, the research categorizes these mutations into metabolic phenotypes to improve personalized medicine and safety for drugs like Clopidogrel.

Zenodo (CERN European Organization for Nuclear Research)
Good health and well-being
Openalex Percentile: Top 22%
Antiplatelet Therapy and Cardiovascular Diseases
DOIOpen Access PDFOpenAlex
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In Silico analysis of CYP2C19 genetic variants and their Impact on Pharmacogenomics — Aakriti Kaushal · Zenodo (CERN European Organization for Nuclear Research) (2026) | TGRS Research Map | TGRS