Risk of CNS relapse following pathological complete response to neoadjuvant chemotherapy in early breast cancer
Although pCR was not associated with a lower overall risk of CNS recurrence, it predicted a reduced risk in HER2-positive disease. Isolated CNS relapse predominated, suggesting a sanctuary effect.
Authors
- Rafael Lima Viana (ORCID: https://orcid.org/0000-0002-2811-2675)
- Marcelle Goldner Cesca
- Sinara Figueiredo Silva
- Rafaela Pirolli (ORCID: https://orcid.org/0000-0002-3668-2002)
- Bruna Raphaeli Silva Mattos (ORCID: https://orcid.org/0000-0002-6131-6485)
- Simone Klug Loose
- Camilla Albina Zanco Fogassa (ORCID: https://orcid.org/0000-0002-5463-1946)
- Débora Maciel Santana Dornellas
- Guilherme Rossato de Almeida (ORCID: https://orcid.org/0009-0000-6073-6130)
- Fernando Augusto Batista Campos (ORCID: https://orcid.org/0000-0002-7771-8059)
- S. Sanches
- Vladmir C. Cordeiro De Lima
- Monique Celeste Tavares
- Erick F. Saldanha
- Luciana de Moura Leite
- Fernanda Alves de Oliveira
- Daniella Dias Sá de Arruda
- Francisca Giselle Rocha Moura
- Maria Fernanda Simões Devides de Held
- Paula Tavares Guimarães
Institutions
- Hospital Israelita Albert Einstein (BR)
- Princess Margaret Cancer Centre (CA)
- AC Camargo Hospital (BR)
- Instituto do Câncer do Estado de São Paulo (BR)
Publication Details
- Journal
- Breast Cancer Research and Treatment
- Published
- 2026-03-23
- DOI
- https://doi.org/10.1007/s10549-026-07915-7
- Primary Topic
- Brain Metastases and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00