β-Hydroxybutyrate upregulates hepatic histone β-hydroxybutyrylation modification, promotes the expression of PPARα, and alleviates the hepatic steatosis in MASLD
BHB alleviates lipid accumulation in the liver of MASLD by promoting the expression of PPARα and its downstream lipid oxidation-related genes in the hepatocytes, which is associated with histone Kbhb modification.
Authors
- Qiming Gong (ORCID: https://orcid.org/0000-0002-0526-7041)
- Yanqiu He
- Wei Huang
- Jidi Wu
- Linqiang Ma
- Yulin Mou
- Yong Xu
- Dongze Li
- Li Zhang
- Tingting Zhou
- Yanqun Li
- Chenlin Gao
Institutions
- Affiliated Hospital of Southwest Medical University (CN)
- First Affiliated Hospital of Sichuan Medical University (CN)
- Yuxian People's Hospital (CN)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2026-03-22
- DOI
- https://doi.org/10.1186/s13148-026-02111-2
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00