Adipose-driven complement-lipid reprogramming controls nociceptive vulnerability in obesity-associated osteoarthritis
We identify an adipose-complement-lipid axis that systemically regulates sensory neuron sensitization, providing a mechanistic basis for pain-structure discordance in obesity-associated osteoarthritis.
Authors
- Hope D. Welhaven (ORCID: https://orcid.org/0000-0001-9330-6903)
- Ashley N. Plumb (ORCID: https://orcid.org/0000-0002-8566-4943)
- S. P. Messier
- Katelyn E. Sadler (ORCID: https://orcid.org/0000-0003-2078-3527)
- Kelsey H. Collins (ORCID: https://orcid.org/0000-0001-7348-7348)
- Ronald K. June (ORCID: https://orcid.org/0000-0003-0752-4109)
- Arin K. Oestreich (ORCID: https://orcid.org/0000-0001-6079-6715)
- Richard F. Loeser (ORCID: https://orcid.org/0000-0003-2832-6144)
- Kristin L. Lenz
- Farshid Guilak (ORCID: https://orcid.org/0000-0001-7380-0330)
- Xiaobo Wu
- Huimin Yan (ORCID: https://orcid.org/0000-0003-0907-1246)
- Jacob G. Brockert
- Antonina Akk (ORCID: https://orcid.org/0000-0002-3721-7620)
- Bethany A. Andoko
- Bo Zhang
- Christine Pham
- John Atkinson
- Luke E Springer
- Joseph B Lesnak
- Darren Dumlao
- Theodore J Price
Institutions
- University of North Carolina at Chapel Hill (US)
- The University of Texas at Dallas (US)
- University of California, San Francisco (US)
- Washington University in St. Louis (US)
- Montana State University (US)
- Virginia Tech - Wake Forest University School of Biomedical Engineering & Sciences (US)
- UCSF Benioff Children's Hospital (US)
- Shriners Hospitals for Children - St. Louis (US)
- Wake Forest University (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-03-21
- DOI
- https://doi.org/10.64898/2026.03.19.712962
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00