Comparative Effectiveness of Ivabradine Versus Digoxin in Patients With Heart Failure With Reduced Ejection Fraction and Chronic Kidney Disease: A Real-World Multicenter Cohort Study

In this large, real-world cohort of patients with HFrEF and CKD, ivabradine was associated with lower risks of MACE, HFE, and all-cause mortality compared with digoxin. Ivabradine may represent a safer and more effective heart-rate-lowering option for this high-risk population.

Authors

Publication Details

Journal
Cardiorenal Medicine
Published
2026-03-21
DOI
https://doi.org/10.1159/000551617
Primary Topic
Heart rate and cardiovascular health
Type
article
Field-Weighted Citation Impact
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article

Comparative Effectiveness of Ivabradine Versus Digoxin in Patients With Heart Failure With Reduced Ejection Fraction and Chronic Kidney Disease: A Real-World Multicenter Cohort Study

Hsuan-Yuan Chang, Keng-Wei Lee, Sheng-Chi Huang, Jheng-Yan Wu et al.
Cardiorenal Medicine
Heart rate and cardiovascular health
article

Comparative Effectiveness of Ivabradine Versus Digoxin in Patients With Heart Failure With Reduced Ejection Fraction and Chronic Kidney Disease: A Real-World Multicenter Cohort Study

Hsuan-Yuan Chang, Keng-Wei Lee, Sheng-Chi Huang, Jheng-Yan Wu, Yu-Min Lin
article en

Abstract

In this large, real-world cohort of patients with HFrEF and CKD, ivabradine was associated with lower risks of MACE, HFE, and all-cause mortality compared with digoxin. Ivabradine may represent a safer and more effective heart-rate-lowering option for this high-risk population.

Cardiorenal Medicine
Good health and well-being
Openalex Percentile: Top 22%
Heart rate and cardiovascular health
DOIOpen Access PDFOpenAlex
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Comparative Effectiveness of Ivabradine Versus Digoxin in Patients With Heart Failure With Reduced Ejection Fraction and Chronic Kidney Disease: A Real-World Multicenter Cohort Study — Hsuan-Yuan Chang, Keng-Wei Lee, et al. · Cardiorenal Medicine (2026) | TGRS Research Map | TGRS