Whole-genome sequence genome-wide association study in <i>All of Us</i> identifies a novel glaucoma risk locus in African ancestry individuals
This study identifies a novel primary open-angle glaucoma risk locus in individuals of African ancestry using whole genome sequencing and varying phenotype definitions in the diverse <i>All of Us</i> Research Program dataset.
Authors
- Yuyang Luo (ORCID: https://orcid.org/0000-0002-3319-5890)
- J. L. Wiggs
- Inas F. Aboobakar (ORCID: https://orcid.org/0000-0002-4556-8818)
- Pirro G. Hysi (ORCID: https://orcid.org/0000-0001-5752-2510)
- Tyler G. Kinzy
- Lauren A. Cruz
- Jessica Tran (ORCID: https://orcid.org/0000-0002-8628-7115)
- Dana C. Crawford (ORCID: https://orcid.org/0000-0002-6437-6248)
- Jessica N. Cooke Bailey (ORCID: https://orcid.org/0000-0002-4001-8702)
- Sanjana Nallapaneni
- Ron Do
- Anthony P Khawaja
- Ha My Vy
- Michael A. Hauser
- Puya Gharahkhani
- Hetince Zhao
- Ayellet V. Segre
- Louis R. Pasquale
Institutions
- Broad Institute (US)
- Massachusetts Eye and Ear Infirmary (US)
- Moorfields Eye Hospital NHS Foundation Trust (GB)
- Harvard University (US)
- Duke University (US)
- East Carolina University (US)
- QIMR Berghofer Medical Research Institute (AU)
- Duke University Hospital (US)
- University College London (GB)
- Case Western Reserve University (US)
- Northeast Ohio Medical University (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- medRxiv
- Published
- 2026-03-22
- DOI
- https://doi.org/10.64898/2026.03.19.26348739
- Primary Topic
- Glaucoma and retinal disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00