Complete NUB1 depletion in ER-negative breast cancer progression in paired primary–metastatic cases: a case series
Loss of NEDD8 ultimate buster 1 in metastases may signal a transition from hypoxia-driven nuclear localization to unchecked metastatic progression. These findings highlight NEDD8 ultimate buster 1 as a potential prognostic marker and therapeutic stratifier, warranting larger studies to confirm its mechanistic and clinical relevance.
Authors
- Md Salzihan Md Salleh (ORCID: https://orcid.org/0000-0001-6691-4962)
- Francesco Pezzella (ORCID: https://orcid.org/0000-0003-1505-7854)
- Maria Arshad (ORCID: https://orcid.org/0000-0003-2779-8123)
- Geok-Chin Ivy Tan
- Azyani Yahaya (ORCID: https://orcid.org/0009-0007-9414-2745)
- Ka-Liong Tan
- Fuad Ismail (ORCID: https://orcid.org/0000-0002-5580-4888)
- Suet Lin Chia
- Amira Raudhah Abdullah
Institutions
- Universiti Sains Islam Malaysia (MY)
- Universiti Putra Malaysia (MY)
- Universiti Sains Malaysia (MY)
- University Kebangsaan Malaysia Medical Centre (MY)
- John Radcliffe Hospital (GB)
- National Cancer Council Malaysia (MY)
Publication Details
- Journal
- Journal of Medical Case Reports
- Published
- 2026-03-22
- DOI
- https://doi.org/10.1186/s13256-026-05939-7
- Primary Topic
- Cell Adhesion Molecules Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00