Dual functions of the Aedes aegypti ecdysone receptor in dengue virus replication and reproduction control

AaEcR functions as a dual regulator of mosquito biology, suppressing antiviral immunity while enhancing reproductive output. This tradeoff between immunity and fecundity highlights AaEcR as a promising molecular target for vector control. Disrupting EcR signaling could simultaneously reduce mosquito population size and limit arboviral transmission, offering a potential strategy for integrated management of mosquito-borne diseases.