Ferroptosis inhibition and mitochondrial rescue: a novel mechanism of emodin in rheumatoid arthritis
EMO ameliorates experimental arthritis mainly by suppressing ferroptosis via the GPX4/ACSL4 axis, highlighting ferroptosis as a previously underappreciated therapeutic target in RA and supporting EMO as a potential adjunctive treatment for RA.
Authors
- Xiaofeng Rong (ORCID: https://orcid.org/0000-0001-9549-8099)
- L B Zhou
- Jing Ren
- Dehao Du
- Jun Liu
Institutions
- Army Medical University (CN)
- Jianghan University (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chinese Journal of Integrated Traditional and Western Medicine (CN)
- Chongqing Medical and Pharmaceutical College (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Redox Report
- Published
- 2026-03-22
- DOI
- https://doi.org/10.1080/13510002.2026.2646383
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00