Causal effects of gut microbiota and blood metabolites on subtypes of perinatal depression classified based on depressive symptom trajectories: a mendelian randomization study
This study establishes evidence for a gut microbiota-blood metabolite-PD subtype regulatory network in East Asian populations. These findings elucidate the heterogeneous mechanisms underlying PD subtypes and provide a foundation for the development of subtype-specific precision interventions.
Authors
- Jianjun Wang (ORCID: https://orcid.org/0000-0001-7039-7136)
- Wenxi Zhou (ORCID: https://orcid.org/0000-0003-3079-6970)
- Bing Lin (ORCID: https://orcid.org/0000-0003-4751-5805)
- Pengxuan Gu
- Ziliang Wu
- Cuicui Gong
- Yuanzhen Mi
- Huakang Li
- Ke Xu
- Jinyi Lang
Institutions
- Southwest Medical University (CN)
- Sichuan Cancer Hospital (CN)
- Chengdu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Nutrition & Metabolism
- Published
- 2026-03-22
- DOI
- https://doi.org/10.1186/s12986-026-01111-6
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00