Sex-specific dynamics of MASLD reveal early hepatic and extrahepatic metabolic deterioration in females despite long-term protection
These findings demonstrate that sexual dimorphism in MASLD arises early and evolves dynamically, with females mounting an acute metabolic and intestinal stress response, whereas males activate compensatory pathways that preserve metabolic homeostasis. These results highlight sex-specific trajectory in MASLD progression and emphasize the need for integrative approaches to unravel its pathophysiology.
Authors
- J Vendrell
- Maria Repollés-de-Dalmau (ORCID: https://orcid.org/0000-0003-1402-0611)
- Anna Marsal-Beltran (ORCID: https://orcid.org/0000-0001-9521-6522)
- Sonia Fernández-Veledo
- Catalina Núñez-Roa
- Victòria Ceperuelo-Mallafré
Institutions
- Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas (ES)
- Institut de Recerca Biomèdica Catalunya Sud (ES)
- Universitat Rovira i Virgili (ES)
Publication Details
- Journal
- Biology of Sex Differences
- Published
- 2026-03-22
- DOI
- https://doi.org/10.1186/s13293-026-00876-y
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00