PTTG3P-miR-142-5p-IGF2BP3 axis governs ferroptosis in hepatocellular carcinoma
The PTTG3P/miR-142-5p/IGF2BP3 axis is a master regulator of ferroptosis in HCC. PTTG3P is a competing endogenous RNA (ceRNA) which sustains IGF2BP3-mediated ferroptosis resistance. Targeting the axis sensitizes HCC to ferroptosis and is potentially a novel therapeutic target to combat treatment resistance.
Authors
- Shifan Shi
- Wenjuan Zhang
- Jiahui Lu
- Shuhan Zhang
- Jian Li
- Zhiyan Li
- Yingmei Gao
- Hao Qiang Liu
- Qiyu Sun
Institutions
- Jianan Mental Hospital (TW)
- Chengde Medical University (CN)
- Air Force General Hospital PLA (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2026-03-22
- DOI
- https://doi.org/10.1007/s12672-026-04902-8
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00