A novel <scp> <i>RHD</i> </scp> allele (c.727 T&gt;G) associated with reduced D antigen expression in a pregnant Chinese woman

The coexistence of the reported RHD*15 allele and a novel missense variant, c.727T>G (p.Tyr243Asp), on different alleles may jointly contribute to reduced RhD antigen expression by affecting protein stability and epitope configuration. Integrating molecular genotyping and structural modelling with conventional serology provides complementary insights into the characterization of novel RHD variants and may provide additional clues for refining the classification of weak D and partial D phenotypes.