MIOLO Standard Formula v2.5 -- Calibrated IOL Power Calculation with Physics-Informed Machine Learning

MIOLO Standard v2.5: Calibrated intraocular lens (IOL) power calculation formula using physics-informed machine learning. This version achieves 280/280 (100%) concordance with Barrett Universal II across 28 strategically selected validation cases spanning AL 21.5-29.0mm, K 39.9-46.9D, ACD 2.5-3.8mm. Key innovations include: (1) 6-term Barrett calibration layer with Kavg*ACD interaction and ACD quadratic modeling, (2) dampening mechanism for long myopic eyes with steep corneas, (3) fade-based short eye protection preserving superior hyperopic performance. Base model (v2.2) coefficients remain unchanged. Formula MLV transformation constitutes protected intellectual property. Supersedes v2.2 (DOI: 10.5281/zenodo.18099603).

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Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-03-22
DOI
https://doi.org/10.5281/zenodo.19172100
Primary Topic
Ophthalmology and Visual Impairment Studies
Type
article
Field-Weighted Citation Impact
0.00
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article

MIOLO Standard Formula v2.5 -- Calibrated IOL Power Calculation with Physics-Informed Machine Learning

Bruno Luiz Miolo
Zenodo (CERN European Organization for Nuclear Research)
Ophthalmology and Visual Impairment Studies
article

MIOLO Standard Formula v2.5 -- Calibrated IOL Power Calculation with Physics-Informed Machine Learning

Bruno Luiz Miolo
article en

Abstract

MIOLO Standard v2.5: Calibrated intraocular lens (IOL) power calculation formula using physics-informed machine learning. This version achieves 280/280 (100%) concordance with Barrett Universal II across 28 strategically selected validation cases spanning AL 21.5-29.0mm, K 39.9-46.9D, ACD 2.5-3.8mm. Key innovations include: (1) 6-term Barrett calibration layer with Kavg*ACD interaction and ACD quadratic modeling, (2) dampening mechanism for long myopic eyes with steep corneas, (3) fade-based short eye protection preserving superior hyperopic performance. Base model (v2.2) coefficients remain unchanged. Formula MLV transformation constitutes protected intellectual property. Supersedes v2.2 (DOI: 10.5281/zenodo.18099603).

Zenodo (CERN European Organization for Nuclear Research)
Universidade Federal de São Paulo (BR)
Openalex Percentile: Top 16%
Ophthalmology and Visual Impairment Studies
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