Macrophage Migration Inhibitory Factor (MIF)-CD74 Signaling Pathway Mediates Trabecular Meshwork Dysfunction in Glaucoma
Our findings identify MIF-CD74 signaling as a previously unrecognized regulator of TM dysfunction in POAG. MIF-mediated suppression of Blimp-1 mechanistically links inflammatory signaling to cytoskeletal contractility and fibrotic ECM remodeling, key determinants of aqueous humor outflow resistance. Targeting the MIF-CD74/Blimp-1 axis may represent a novel therapeutic strategy to restore TM homeostasis and reduce intraocular pressure in glaucoma.
Authors
- Lal Krishan Kumar
- Gulab Zode (ORCID: https://orcid.org/0000-0002-7823-2595)
- Pawan Kumar Singh (ORCID: https://orcid.org/0000-0002-4805-1611)
- Monu Monu
- Prince Kumar
Institutions
- University of California, Irvine (US)
- University of Missouri (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-03-20
- DOI
- https://doi.org/10.64898/2026.03.18.712673
- Primary Topic
- Macrophage Migration Inhibitory Factor
- Type
- article
- Field-Weighted Citation Impact
- 0.00