What is new in Freezing of Gait?

Freezing of Gait (FOG) research is entering a rapidly evolving phase. Published in early 2026, the International Consortium for FOG (ICFOG) released updated clinical and technical definitions of FOG and introduced a consensus-based standardized testing protocol, the Giladi protocol (GP-FOG), which is currently still under evaluation in an ongoing study. Complementing these advances, two new outcome measures, the clinician-reported outcome (ClinRO) and the patient-reported outcome (PRO), are highlighted in this review. Recent technological developments in both detection and potential prevention of FOG are moving the field toward individualized, biomarker-based, on-demand treatment strategies. In addition, emerging insights into the pathophysiological mechanisms of FOG, particularly nondopaminergic contributions, are discussed. Together, these developments provide a contemporary framework for improving the assessment, understanding, and personalized management of FOG in Parkinson's disease.

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Publication Details

Journal
Journal of Neurology
Published
2026-03-21
DOI
https://doi.org/10.1007/s00415-026-13765-6
Primary Topic
Parkinson's Disease Mechanisms and Treatments
Type
article
Field-Weighted Citation Impact
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article

What is new in Freezing of Gait?

Eileen Gülke, Simon J. G. Lewis
Journal of Neurology
Parkinson's Disease Mechanisms and Treatments
article

What is new in Freezing of Gait?

Eileen Gülke, Simon J. G. Lewis
article en

Abstract

Freezing of Gait (FOG) research is entering a rapidly evolving phase. Published in early 2026, the International Consortium for FOG (ICFOG) released updated clinical and technical definitions of FOG and introduced a consensus-based standardized testing protocol, the Giladi protocol (GP-FOG), which is currently still under evaluation in an ongoing study. Complementing these advances, two new outcome measures, the clinician-reported outcome (ClinRO) and the patient-reported outcome (PRO), are highlighted in this review. Recent technological developments in both detection and potential prevention of FOG are moving the field toward individualized, biomarker-based, on-demand treatment strategies. In addition, emerging insights into the pathophysiological mechanisms of FOG, particularly nondopaminergic contributions, are discussed. Together, these developments provide a contemporary framework for improving the assessment, understanding, and personalized management of FOG in Parkinson's disease.

Journal of NeurologyVol. 273(4)
Universität Hamburg (DE), Universitätsmedizin Greifswald (DE), University Medical Center Hamburg-Eppendorf (DE), Macquarie University (AU)
Partnerships for the goals
Openalex Percentile: Top 22%
Parkinson's Disease Mechanisms and Treatments
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