Dedifferentiated liposarcoma originating in the prostate: a rare case report

Dedifferentiated liposarcoma (DDLPS) is an aggressive subtype of liposarcoma, associated with high rates of recurrence and metastasis, that most commonly occurs in the extremities and retroperitoneum. Here we report a 41-year-old Chinese male who was found to have a prostatic mass on imaging evaluation. Following radical prostatectomy, histopathological examination revealed that the tumor predominantly exhibited low-grade spindle cell morphology, with focal areas showing well-differentiated liposarcoma components. Immunohistochemical analysis demonstrated positivity for MDM2 and CDK4 in the tumor cells, and next-generation sequencing (NGS) further confirmed the amplification of both CDK4 and MDM2 genes. Based on these findings, a diagnosis of DDLPS was made. The prostate is an exceptionally rare site for DDLPS. To our knowledge, this represents the first reported case of DDLPS originating in the prostate, which may provide valuable diagnostic insights for pathologists.