Prospective Study of Atezolizumab Plus Bevacizumab for Unresectable Hepatocellular Carcinoma Based on Hepatobiliary Phase of Gd‐EOB‐DTPA‐MRI
This prospective multicenter study demonstrates that hepatobiliary hyperintensity on Gd-EOB-DTPA-enhanced MRI-an imaging surrogate of Wnt/β-catenin activation-does not indicate resistance to atezolizumab plus bevacizumab. These findings support the use of combination immunotherapy in molecularly "immune-cold" HCC.
Authors
- Norio Itokawa (ORCID: https://orcid.org/0009-0002-2390-6692)
- Takashi Aoki (ORCID: https://orcid.org/0000-0003-0357-3245)
- Masakatsu Tsurusaki (ORCID: https://orcid.org/0000-0001-9894-4912)
- Keitaro Sofue (ORCID: https://orcid.org/0000-0001-6132-1623)
- Yoshihiko Yano (ORCID: https://orcid.org/0000-0002-5177-7480)
- Toru Ishikawa
- Satoru Hagiwara
- Masanori Atsukawa
- Masahiro Morita
- Yasunori Minami
- Joji Tani
- Takeshi Hatanaka
- Atsushi Hiraoka
- Yuzo Kodama
- Kazuto Tajiri
- Satoru Kakizaki
- Hidenori Toyoda
- Atsushi Naganuma
- Kazuhito Kawata
- Masatoshi Kudo
- Masahiro Takita
- Hirokazu Chishina
- Naoshi Nishida
- Takashi Kumada
- Kazuomi Ueshima
Institutions
- Kansai Medical University (JP)
- Kagawa University (JP)
- Hamamatsu University School of Medicine (JP)
- Saiseikai Niigata Daini Hospital (JP)
- National Hospital Organization Takasaki Medical Center (JP)
- Ogaki Municipal Hospital (JP)
- Gunma Saiseikai Maebashi Hospital (JP)
- Toyama University Hospital (JP)
- Ehime Prefectural Central Hospital (JP)
- Gifu Kyoritsu University (JP)
- Kobe University (JP)
- The University of Tokyo (JP)
- Nippon Medical School (JP)
- Kindai University (JP)
Publication Details
- Journal
- Hepatology Research
- Published
- 2026-03-20
- DOI
- https://doi.org/10.1111/hepr.70157
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00