Tetrahedral framework nucleic acid delivery of emodin enables precision antibacterial and anti-inflammatory therapy for drug-resistant Staphylococcus aureus

Overall, this study establishes an aptamer-targeted nucleic acid nanoplatform that integrates antimicrobial delivery, biofilm disruption, and host immunomodulation, offering a promising therapeutic strategy for multidrug-resistant S. aureus skin infections.

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Publication Details

Journal
Journal of Nanobiotechnology
Published
2026-03-21
DOI
https://doi.org/10.1186/s12951-026-04278-5
Primary Topic
RNA Interference and Gene Delivery
Type
article
Field-Weighted Citation Impact
0.00
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article

Tetrahedral framework nucleic acid delivery of emodin enables precision antibacterial and anti-inflammatory therapy for drug-resistant Staphylococcus aureus

Zhangyu Du, Dongbin Guo, Bingmei Wang, Yuan Gao et al.
Journal of Nanobiotechnology
RNA Interference and Gene Delivery
article

Tetrahedral framework nucleic acid delivery of emodin enables precision antibacterial and anti-inflammatory therapy for drug-resistant Staphylococcus aureus

Zhangyu Du, Dongbin Guo, Bingmei Wang, Yuan Gao, Peitong Jiang, Changfeng Zhu, Luanbiao Sun, Yicheng Zhao, Li Wang, Ye Jin, Yun Sun, Xinyao Liu, Han Gao
article en

Abstract

Overall, this study establishes an aptamer-targeted nucleic acid nanoplatform that integrates antimicrobial delivery, biofilm disruption, and host immunomodulation, offering a promising therapeutic strategy for multidrug-resistant S. aureus skin infections.

Journal of Nanobiotechnology
Guangzhou University of Chinese Medicine (CN), Union Hospital (HK), Sun Yat-sen University (CN), Jilin University (CN), Fudan University (CN), Zhongshan Hospital (CN), Changchun University of Chinese Medicine (CN), The First Affiliated Hospital, Sun Yat-sen University (CN)
Good health and well-being
Openalex Percentile: Top 14%
RNA Interference and Gene Delivery
DOIOpen Access PDFOpenAlex
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