An improved fully-automated GMP radiosynthesis of [18F]fluoro-pivalic acid with solid-phase extraction purification
The synthesis of [<sup>18</sup>F]FPIA was validated on the Trasis AIO™ platform for GMP production and is currently used to produce clinical doses for phase II clinical trials. Readiness for GMP validation was also demonstrated on GE FASTlab™ and can be adopted on other automated platforms.
Authors
- Matthias Glaser (ORCID: https://orcid.org/0009-0008-4463-989X)
- Louis Allott (ORCID: https://orcid.org/0000-0002-1025-0738)
- Frazer Twyman
- David R. Turton
- Ramla Awais
- Erik Årstad (ORCID: https://orcid.org/0000-0002-3240-2106)
- D. F. L. Pritchard
- E. Aboagye
- Graham Smith
- Diana Brickute
- Chris Barnes
Institutions
- Institute of Cancer Research (GB)
- University of Hull (GB)
- University of Cambridge (GB)
- Hammersmith Hospital (GB)
- University College London (GB)
- Imperial College London (GB)
Publication Details
- Journal
- EJNMMI Radiopharmacy and Chemistry
- Published
- 2026-03-21
- DOI
- https://doi.org/10.1186/s41181-026-00440-4
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00