Analysis of the relationship between body composition and the pharmacokinetics of panitumumab in the treatment of localized squamous cell carcinoma of the anus – An ancillary study of the FFCD0904 phase I and II trial

This exploratory analysis suggests that BW and BC may influence panitumumab PK, with patients who had lower BW, FM and FFM might have reduced exposure and clearance. Interpretation should be cautious due to the small sample size, confounding effect between BC and BW and potential disease-related effects. Larger studies with longitudinal BC and PK assessments are needed to clarify these relationships and guide dosing strategies.

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Publication Details

Journal
Biomedicine & Pharmacotherapy
Published
2026-03-21
DOI
https://doi.org/10.1016/j.biopha.2026.119242
Primary Topic
Colorectal and Anal Carcinomas
Type
article
Field-Weighted Citation Impact
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article

Analysis of the relationship between body composition and the pharmacokinetics of panitumumab in the treatment of localized squamous cell carcinoma of the anus – An ancillary study of the FFCD0904 phase I and II trial

Méher Ben Abdelghani, C. Lemanski, Louis Bazire, Adeline Dolly et al.
Biomedicine & Pharmacotherapy
Colorectal and Anal Carcinomas
article

Analysis of the relationship between body composition and the pharmacokinetics of panitumumab in the treatment of localized squamous cell carcinoma of the anus – An ancillary study of the FFCD0904 phase I and II trial

Méher Ben Abdelghani, C. Lemanski, Louis Bazire, Adeline Dolly, Gilles Paintaud, T. Aparicio, K. Le Malicot, Nicolas Azzopardi, Astrid Lièvre, Sarah Lobet, C. de la Fouchardiere, D. Ternant, Lucie Lagogué, Franck Nguyen, Jérôme Martin-Babau, Come Lepage, Thierry Lecomte, Véronique Vendrely
article en

Abstract

This exploratory analysis suggests that BW and BC may influence panitumumab PK, with patients who had lower BW, FM and FFM might have reduced exposure and clearance. Interpretation should be cautious due to the small sample size, confounding effect between BC and BW and potential disease-related effects. Larger studies with longitudinal BC and PK assessments are needed to clarify these relationships and guide dosing strategies.

Biomedicine & PharmacotherapyVol. 198
Université de Tours (FR), Centre National de la Recherche Scientifique (FR), Inserm (FR), Centre Hospitalier Universitaire de Bordeaux (FR), Université Rennes 2 (FR), Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR), Institut de Cancérologie Strasbourg (FR), Centre Hospitalier Universitaire de Tours (FR), Assistance Publique – Hôpitaux de Paris (FR), Physiologie de la Reproduction et des Comportements (FR), Fédération Francophone de Cancérologie Digestive (FR), Hôpital Privé Jean Mermo (FR), Thion Medical (France) (FR), Institut de Recherche en Cancérologie de Montpellier (FR), Hôpital Saint-Louis (FR), Institut Paoli-Calmettes (FR), Centre Hospitalier Universitaire de Rennes (FR), Université de Rennes (FR), Institut Curie (FR)
Good health and well-being
Openalex Percentile: Top 14%
Colorectal and Anal Carcinomas
DOIOpen Access PDFOpenAlex
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