Pregnancy and epilepsy: pharmacokinetic insights into antiseizure medications
Therapeutic drug monitoring is a valuable tool for tailoring antiseizure treatment in women with epilepsy. When monitoring is not feasible, clinicians may need to adjust doses based on seizure severity and the well-documented pharmacokinetic changes of specific medications such as lamotrigine, levetiracetam, oxcarbazepine. The goal is to maintain effective seizure control while minimizing teratogenic risks and ensuring safe fetal development.
Authors
- Bruna Nucera (ORCID: https://orcid.org/0000-0002-6023-5616)
- Giovanni Falcicchio (ORCID: https://orcid.org/0000-0003-0745-5246)
- Isabella Colonna (ORCID: https://orcid.org/0000-0001-9390-9341)
- Giovanni Castellucci (ORCID: https://orcid.org/0000-0002-3031-5113)
- Emilio Russo
- Loretta Giuliano
Institutions
- Baylor College of Medicine (US)
- University of Ferrara (IT)
- Paracelsus Medical University (AT)
- Magna Graecia University (IT)
- Texas Children's Hospital (US)
- Universidad San Marcos (CR)
- University of Bari Aldo Moro (IT)
Publication Details
- Journal
- Expert Opinion on Drug Metabolism & Toxicology
- Published
- 2026-03-21
- DOI
- https://doi.org/10.1080/17425255.2026.2650186
- Primary Topic
- Pharmacological Effects and Toxicity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00