A multifaceted kinase keeps molecular motors in place for faithful cell division
During cell division, faithful chromosome segregation is ensured by the mitotic spindle. van Toorn et al.<sup>1</sup> uncovered that Cdk1-mediated phosphorylation of the dynein-activating adaptor NuMA promotes the timely assembly of dynein/dynactin/NuMA complexes, essential for correct mitotic progression and genome integrity.
Authors
- Marina Mapelli (ORCID: https://orcid.org/0000-0001-8502-0649)
- Paola Ghezzi
Publication Details
- Journal
- Cell Reports
- Published
- 2026-03-21
- DOI
- https://doi.org/10.1016/j.celrep.2026.117214
- Primary Topic
- Microtubule and mitosis dynamics
- Type
- article
- Field-Weighted Citation Impact
- 0.00