Single-center retrospective cohort study of lung cancer associated with interstitial lung disease: Prognostic factors and molecular profile

KCO and performance status are the strongest independent predictors of survival in LC-ILD. AREs are frequent and highly lethal. Dedicated therapeutic guidelines and an adapted ILD-GAP-cancer prognostic tool are urgently needed. Beyond clinical parameters our findings suggest a distinct molecular landscape dominated by TP53, KRAS and PI3K pathway alteration.

Authors

Institutions

Publication Details

Journal
Lung Cancer
Published
2026-03-21
DOI
https://doi.org/10.1016/j.lungcan.2026.109379
Primary Topic
Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Single-center retrospective cohort study of lung cancer associated with interstitial lung disease: Prognostic factors and molecular profile

M. Reynaud-Gaubert, E. Pollien, M. Barboni, A. Goga et al.
Lung Cancer
Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
article

Single-center retrospective cohort study of lung cancer associated with interstitial lung disease: Prognostic factors and molecular profile

M. Reynaud-Gaubert, E. Pollien, M. Barboni, A. Goga, J. Milesi, J. Pluvy, P. Tomasini, G. Soussi, J. Bermudez, L. Greillier, P. Habert, E. Gouton, A. Fourdrain, A. Mogenet, R. Naud, B. Coiffard
article en

Abstract

KCO and performance status are the strongest independent predictors of survival in LC-ILD. AREs are frequent and highly lethal. Dedicated therapeutic guidelines and an adapted ILD-GAP-cancer prognostic tool are urgently needed. Beyond clinical parameters our findings suggest a distinct molecular landscape dominated by TP53, KRAS and PI3K pathway alteration.

Lung CancerVol. 215
Centre National de la Recherche Scientifique (FR), Inserm (FR), Aix-Marseille Université (FR), Fondation FondaMental (FR), Hôpital Nord (FR), Centre de Recherche en Cancérologie de Marseille (FR)
Good health and well-being
Openalex Percentile: Top 15%
Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.