Regenerative High Purity Type I Collagen Scaffold for Breast Cancer Excision Repair and Reconstruction: A Prospective Multicenter Clinical Trial

HPTC scaffold implantation following BCS demonstrates excellent safety, robust early volume restoration (88.6% retention at two months), progressive biological integration, and clinically meaningful improvement in patient satisfaction. This minimally invasive regenerative approach avoids donor-site morbidity while achieving outcomes comparable to traditional oncoplastic techniques, warranting evaluation in randomized controlled trials with longer follow-up to assess durability and radiotherapy response.