Circulating cardiometabolic metabolite profiles associated with ambient air pollution and atrial fibrillation risk: a prospective cohort study
Air pollution-related metabolic signature was independently associated with AF risk and mediated a significant portion of pollution's arrhythmogenic effects. These findings provide novel insights into biological mechanisms linking environmental exposures to AF.
Authors
- Marcel Sieme (ORCID: https://orcid.org/0000-0002-8253-879X)
- Loek van Heerebeek (ORCID: https://orcid.org/0000-0001-6718-2871)
- Assem Aweimer (ORCID: https://orcid.org/0000-0002-8134-6905)
- Melina Tangos
- Andreas Mügge (ORCID: https://orcid.org/0000-0001-9548-6995)
- Francesco Paneni (ORCID: https://orcid.org/0000-0001-6483-7844)
- Jan Wintrich (ORCID: https://orcid.org/0000-0001-6518-1453)
- Benjamin Sasko (ORCID: https://orcid.org/0000-0001-8157-9875)
- Nazha Hamdani
- Muchtiar Khan
- Dizhe Huang
- Giuseppe Danilo Norata
- Kai Huang
- Xingyue Wu
- Chaojun Yang
- Xinyi Liu
- Ulrich Schotten
- Ibrahim Akin
- Zhixing Fan
- Tonghuan Shi
- Ibrahim El-Battrawy
- Miao Lin
- Jian Yang
Institutions
- China Three Gorges University (CN)
- Yanbian University (CN)
- University of Milan (IT)
- University of Zurich (CH)
- University Hospitals of the Ruhr-University of Bochum (DE)
- United Nations University – Maastricht Economic and Social Research Institute on Innovation and Technology (NL)
- Southwest Medical University (CN)
- Maastricht University (NL)
- Wuhan University (CN)
- Universitätsklinik Marien Hospital Herne (DE)
- University Hospital of Zurich (CH)
- Hubei Provincial Center for Disease Control and Prevention (CN)
- Second Hospital of Yichang (CN)
- OLVG (NL)
- St. Josef-Hospital (DE)
- BG University Hospital Bergmannsheil Bochum (DE)
- Renmin Hospital of Wuhan University (CN)
- Ospedale Bassini (IT)
- University Medical Centre Mannheim (DE)
- Huazhong University of Science and Technology Hospital (CN)
- Huazhong University of Science and Technology (CN)
- Hubei University (CN)
- Ruhr University Bochum (DE)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2026-03-21
- DOI
- https://doi.org/10.1186/s12933-026-03129-9
- Primary Topic
- Air Quality and Health Impacts
- Type
- article
- Field-Weighted Citation Impact
- 0.00