The Impact of Sex and Age on Antipsychotic Serum Concentrations
We found sex differences in olanzapine and clozapine concentrations, which were most pronounced until 45 years of age. Our findings suggest that monitoring antipsychotic levels may add clinical value and underscore the need for sex-specific prescription guidelines for olanzapine and clozapine.
Authors
- PHAMOUS investigators
- F. Jörg
- Franciska de Beer (ORCID: https://orcid.org/0000-0002-0740-0969)
- Ellen Visser
- D. Touw
- G. Schoretsanitis
- Iris E. C. Sommer
- Gerdina H. M. Pijnenborg
- Stynke Castelein
- Wim Veling
- Edith Liemburg
- Sander de Vos
- Bodyl A Brand
- Shiral S Gangadin
- Lisette van der Meer
- Ben Wijnen
Institutions
- University Medical Center Groningen (NL)
- University of Groningen (NL)
- University of Zurich (CH)
- University of Oxford (GB)
- University Hospital of Zurich (CH)
- Trimbos Institute (NL)
- Zucker Hillside Hospital (US)
Publication Details
- Journal
- Schizophrenia Bulletin
- Published
- 2025-11-21
- DOI
- https://doi.org/10.1093/schbul/sbaf217
- Primary Topic
- Schizophrenia research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00