Towards high-quality and timely interim analyses in adaptive trials: a scoping review of best practice and evidence gaps
The currently available data suggest that although there is a considerable volume of evidence with regards to the conduct of adaptive trials and good trial management, the existing literature base offers limited specific guidance for interim analyses. There are significant gaps in the literature regarding best practice guidance related to PPIE and statistical considerations in adaptive trials. While there are examples of innovative methods speeding up the collation and analysis of data used for interim analyses, we advocate more robust research exploring the operational opportunities and challenges with regards to undertaking adaptive trials.
Authors
- Matthew Breckons (ORCID: https://orcid.org/0000-0003-3057-6767)
- Helen Hancock (ORCID: https://orcid.org/0000-0002-1494-8551)
- M. Dawn Teare (ORCID: https://orcid.org/0000-0003-3994-0051)
- Helen Mossop (ORCID: https://orcid.org/0000-0002-6260-3734)
- Katie Thomson (ORCID: https://orcid.org/0000-0002-9614-728X)
- Michelle Bardgett (ORCID: https://orcid.org/0000-0003-1393-2010)
- Chizoba Oparah (ORCID: https://orcid.org/0009-0008-9993-7683)
- Julia Phillipson
- Opeyemi Agbeleye (ORCID: https://orcid.org/0009-0008-6529-427X)
- Zoë Walmsley (ORCID: https://orcid.org/0000-0002-1253-6668)
- Alex Bevin-Nicholls
- Alex Inskip
- Dawn Craig
- James M. S. Wason
- Nina Wilson
Institutions
- Newcastle University (GB)
Publication Details
- Journal
- Trials
- Published
- 2026-03-21
- DOI
- https://doi.org/10.1186/s13063-026-09643-1
- Primary Topic
- Statistical Methods in Clinical Trials
- Type
- article
- Field-Weighted Citation Impact
- 0.00