Longitudinal Trajectories of Cortical Folding in Schizophrenia Spectrum Disorders: A 13-Year Follow-Up Study
In the longest longitudinal study on cortical folding in SSD patients to date, we found no evidence for accelerated progressive decline in cortical folding. Rather, chronic SSD appears to be characterized by a state of stable hypogyria relative to healthy controls, consistent with the interpretation of LGI as a marker of early gyrification disturbances in SSD.
Authors
- Pravesh Parekh (ORCID: https://orcid.org/0000-0002-1930-1167)
- Daniela Mier (ORCID: https://orcid.org/0000-0003-2518-7492)
- Laura A. Wortinger (ORCID: https://orcid.org/0000-0003-2721-3172)
- Cláudia Barth (ORCID: https://orcid.org/0000-0001-6544-0945)
- I. Agartz
- Lena Palaniyappan (ORCID: https://orcid.org/0000-0003-1640-7182)
- Erik G Jönsson
- Stener Nerland
- Kjetil N Jørgensen
- Lara A Wallenwein
Institutions
- Western University (CA)
- Lawson Health Research Institute (CA)
- OsloMet – Oslo Metropolitan University (NO)
- University of Oslo (NO)
- University of Konstanz (DE)
- Douglas Mental Health University Institute (CA)
- Vestre Viken Hospital Trust (NO)
- Diakonhjemmet Hospital (NO)
- Stockholm Health Care Services (SE)
Publication Details
- Journal
- Schizophrenia Bulletin
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1093/schbul/sbaf245
- Primary Topic
- Schizophrenia research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00