BAF complexes maintain accessibility at stimulus-responsive chromatin and are required for transcriptional stimulus responses
Collectively, our results demonstrate a requirement for continuous BAF activity to enable stimulus response and suggest that defective signal responsiveness may be a pathogenic mechanism in disease states caused by loss-of-function mutations in BAF subunits.
Authors
- Ziben Zhou (ORCID: https://orcid.org/0000-0001-8829-5330)
- Alexander O. D. Gulka (ORCID: https://orcid.org/0000-0003-2926-1047)
- David U. Gorkin (ORCID: https://orcid.org/0000-0003-4944-4107)
- Kihoon Kang
Institutions
- Emory University (US)
- Emory and Henry College (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-03-21
- DOI
- https://doi.org/10.64898/2026.03.19.712964
- Primary Topic
- Chromatin Remodeling and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00