TLC‐Bioautography–Guided Natural Product Discovery: An Integrated Platform for Rapid Profiling of Plant‐Derived Phosphodiesterase Inhibitors
The developed TLC-B platform effectively combines chromatographic separation with bioactivity mapping, creating a streamlined workflow for the discovery of natural product-based enzyme inhibitors. It demonstrates significant potential for accelerating pharmaceutical development.
Authors
- Sahyun Kim
- Ling Chen (ORCID: https://orcid.org/0000-0002-6468-5729)
- Ziheng Yang (ORCID: https://orcid.org/0000-0003-3351-7981)
- Qi Wang (ORCID: https://orcid.org/0000-0002-1328-8571)
- Lu Liu (ORCID: https://orcid.org/0009-0003-4007-0329)
- Yuxin Yuan
- Tian‐Kun Zhao
- Bing Sun
- Jian‐Guo Chen
- Cui‐Juan Xu
- Yong‐Jiao Niu
- Ai‐Hong Zhao
Institutions
- Wenzhou University (CN)
- Lanzhou University of Technology (CN)
- Kyungpook National University (KR)
Publication Details
- Journal
- Phytochemical Analysis
- Published
- 2026-03-20
- DOI
- https://doi.org/10.1002/pca.70068
- Primary Topic
- Phosphodiesterase function and regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00