TRIM21-Mediated ubiquitination of FBL suppresses PI3K/AKT signaling and tumor progression in clear cell renal cell carcinoma
The TRIM21-FBL axis regulates ccRCC progression by modulating PI3K/AKT signaling, providing mechanistic insight and potential therapeutic targets for ribosome biogenesis and oncogenic signaling.
Authors
- Zhen Yuan
- Xiaowei Li (ORCID: https://orcid.org/0000-0001-9097-6856)
- Zongyao Hao
- Jun Yao
- Haoda Tang
- Bo Guan
- Di Cui
Institutions
- Fuyang Normal University (CN)
- Anhui Medical University (CN)
- Fuyang City People's Hospital (CN)
- Fuyang Maternity and Child Health Care Hospital (CN)
- Anhui Institute of Architectural Research and Design (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Fuyang Second People's Hospital (CN)
Publication Details
- Journal
- Cellular and Molecular Life Sciences
- Published
- 2026-03-21
- DOI
- https://doi.org/10.1007/s00018-026-06113-4
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00