Targeting p75NTR activity alleviates the neurotoxic effect of high glucose on iPSC-derived dopaminergic neurons
Our findings show that high glucose impairs human dopaminergic neuron survival through activation of the pro-NGF/p75NTR axis and indirect glia-mediated mechanisms. Targeting p75NTR signaling may offer neuroprotective benefits in diabetes-related neurodegeneration, particularly for patients at risk of Parkinson's disease.
Authors
- Alexandros Tsimpolis (ORCID: https://orcid.org/0000-0001-6346-7714)
- Chrystalla Konstantinou
- Matthieu D. Lavigne (ORCID: https://orcid.org/0000-0003-1543-8745)
- Ioannis Charalampopoulos (ORCID: https://orcid.org/0000-0003-3415-7332)
- Maria Tziortziou (ORCID: https://orcid.org/0000-0002-2443-0983)
- Katerina Ntarntani
- Ioanna Zota (ORCID: https://orcid.org/0009-0003-0215-5735)
- Electra Tsagliotis
- Anne Grünewald
- Achille Gravanis
- Maria Anna Papadopoulou
- Konstantina Chanoumidou
Institutions
- University of Crete (GR)
- University of Luxembourg (LU)
- FORTH Institute of Molecular Biology and Biotechnology (GR)
- Institute of Molecular Biology and Biotechnology (BG)
- Foundation for Research and Technology Hellas (GR)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2026-03-21
- DOI
- https://doi.org/10.1186/s13287-026-04965-y
- Primary Topic
- Nerve injury and regeneration
- Type
- article
- Field-Weighted Citation Impact
- 0.00