Spongiotic Dermatitis: An Underrecognized Cutaneous Manifestation of Severe Uremia

ABSTRACT Spongiotic dermatitis may represent an underrecognized cutaneous manifestation of severe uremia. While uremic pruritus typically presents without primary skin eruptions, extreme uremic toxin accumulation can trigger inflammatory dermatologic changes. Recognition of atypical skin findings in chronic kidney disease patients may indicate systemic disease severity requiring urgent intervention.