The dysregulation of tetrahydrobiopterin biosynthesis exacerbates the progression of chronic liver disease by modulating choline metabolism pathways and inflammatory responses
Disruption of lipid and choline metabolism, alongside immune modulation, suggests that targeting the SPR/BH4 pathway may offer therapeutic potential for managing chronic liver diseases.
Authors
- Lei Li (ORCID: https://orcid.org/0000-0001-8723-3461)
- Jie Jiang (ORCID: https://orcid.org/0000-0002-4077-0056)
- Zongqiang Hu
Institutions
- Kunming Medical University (CN)
Publication Details
- Journal
- Current Medicinal Chemistry
- Published
- 2026-03-16
- DOI
- https://doi.org/10.2174/0109298673430193260110025915
- Primary Topic
- Metabolism and Genetic Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00