Proteomic Profiling of PTEN Inhibition on Periodontal Ligament Stem Cells
In conclusion, PTEN inhibition by VO-OHpic was associated with proteomic changes in PDLSCs linked to regenerative phenotype, including the modulation of MAPK and Wnt signalling pathways alongside alterations in immune and metabolic pathways. These findings suggest that PTEN may function as a modulator balancing inflammatory regulation and differentiation processes, providing mechanistic insight into its potential role in periodontal tissue regeneration.
Authors
- Chatvadee Kornsuthisopon (ORCID: https://orcid.org/0000-0002-4656-8158)
- Suphalak Phothichailert (ORCID: https://orcid.org/0009-0001-1581-634X)
- Nunthawan Nowwarote (ORCID: https://orcid.org/0000-0001-5315-5565)
- Thanaphum Noom Osathanon (ORCID: https://orcid.org/0000-0003-1649-6357)
- Supreda Suphanantachat Srithanyarat (ORCID: https://orcid.org/0000-0001-6272-8169)
- Shinya Murakami
Institutions
- Inserm (FR)
- Chulalongkorn University (TH)
- Université Paris Cité (FR)
- Institut des Maladies Génétiques Imagine (FR)
Publication Details
- Journal
- International Dental Journal
- Published
- 2026-03-20
- DOI
- https://doi.org/10.1016/j.identj.2026.109493
- Primary Topic
- PI3K/AKT/mTOR signaling in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00