The potential effect and pathway of valsartan: genome-wide and phenome-wide association study from UK Biobank data
Our genetic-based study suggests valsartan use may be associated with lowered LDL-C and reduced risks of certain ischemic cardiovascular events. These findings generate novel hypotheses regarding the drug's pleiotropic effects and potential applications beyond hypertension management, which warrant further clinical investigation.
Authors
- Yueqi Lu (ORCID: https://orcid.org/0000-0001-9765-7532)
- Lei Ruan (ORCID: https://orcid.org/0000-0001-6279-1950)
- Bangwei Chen (ORCID: https://orcid.org/0000-0003-4348-2938)
- Tong Li (ORCID: https://orcid.org/0000-0002-8988-234X)
- Yaxin Li (ORCID: https://orcid.org/0000-0003-0249-7148)
- Shengyin Zeng
- Cuntai Zhang
- Jianguo Zhang
- Yucong Zhang
Institutions
- BGI Group (China) (CN)
- Tongji Hospital (CN)
- University of Chinese Academy of Sciences (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Pharmacogenetics and Genomics
- Published
- 2026-03-20
- DOI
- https://doi.org/10.1097/fpc.0000000000000597
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00