What is the significance of a new breast mass in women aged 40 or above? A cross-sectional study

While our institutional protocol increased the sensitivity and could lead to early detection, it lowered specificity, suggesting more false positive results. Our main suggestion is to consider "recency of a solid mass" as a criterion for suspiciousness in BI-RADS assignment to breast masses. We propose further studies to achieve a protocol that maximizes both sensitivity and specificity without compromising diagnostic reliability, and to find the cut-off for age when the effect of this factor increases.

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Publication Details

Journal
PLoS ONE
Published
2026-03-20
DOI
https://doi.org/10.1371/journal.pone.0341732
Primary Topic
Breast Lesions and Carcinomas
Type
article
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article

What is the significance of a new breast mass in women aged 40 or above? A cross-sectional study

Amirhossein Eskandari, Mandana Motamedi, Azin Saberi, Sadaf Alipour et al.
PLoS ONE
Breast Lesions and Carcinomas
article

What is the significance of a new breast mass in women aged 40 or above? A cross-sectional study

Amirhossein Eskandari, Mandana Motamedi, Azin Saberi, Sadaf Alipour, Kasra Jafari
article en

Abstract

While our institutional protocol increased the sensitivity and could lead to early detection, it lowered specificity, suggesting more false positive results. Our main suggestion is to consider "recency of a solid mass" as a criterion for suspiciousness in BI-RADS assignment to breast masses. We propose further studies to achieve a protocol that maximizes both sensitivity and specificity without compromising diagnostic reliability, and to find the cut-off for age when the effect of this factor increases.

PLoS ONEVol. 21(3)
Ministry of Health and Medical Education (IR), Motamed Cancer Institute (IR), Tehran University of Medical Sciences (IR)
Gender equality
Openalex Percentile: Top 15%
Breast Lesions and Carcinomas
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