DS96432529 enhances osteogenic differentiation and mitigates inflammatory damage in periodontal ligament stem cells involving mitophagy-related processes
DS enhances the osteogenic potential of PDLSCs in association with the activation of mitophagy-related processes. It mitigates inflammation-impaired osteogenesis, potentially via modulation of the RIG-I-mediated RLR signaling pathway, in association with increased mitophagy-related activity. DS represents a potent therapeutic small molecule for ameliorating periodontitis-induced bone loss.
Authors
- Yichi Zhou (ORCID: https://orcid.org/0000-0003-2470-657X)
- Tianyong Hu
- Jiamin Huang
- Jingyi Yuan (ORCID: https://orcid.org/0000-0002-2850-1582)
- Dongcai Li
- Baohui Cheng
- Liu Shi
- Haipeng He
- Yanyan Chen
- Zhiqiang Liu
- Dunhui Yang
- Xiao Chen
- Meizhen Zhao
- Xianhai Zeng
Institutions
- Beijing University of Chinese Medicine (CN)
- Zunyi Medical University (CN)
- Longgang Central Hospital (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2026-03-20
- DOI
- https://doi.org/10.1186/s13287-026-04988-5
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00