Cognitive function is associated with risk of conversion to secondary progressive multiple sclerosis: A cross-sectional study
In conclusion, low cognitive performance across the BICAMS battery and the PASAT, with the SDMT as the most robust predictor, is associated with an increased risk of conversion from RRMS to SPMS. By demonstrating this association through a machine-learning framework, the present study supports the integration of standardized neuropsychological assessments into routine clinical practice as tools for monitoring conversion risk in PwMS, beyond conventional clinical measures.
Authors
- Ida Mohammadi (ORCID: https://orcid.org/0000-0002-0662-0329)
- Saeed Vaheb (ORCID: https://orcid.org/0000-0001-5738-7419)
- Mohammad Yazdan Panah (ORCID: https://orcid.org/0000-0001-9112-9544)
- Tom A. Fuchs (ORCID: https://orcid.org/0000-0002-0219-3518)
- Shahryar Rajai Firouzabadi (ORCID: https://orcid.org/0000-0001-6511-4103)
- Vahid Shaygannejad
- Omid Mirmosayyeb
- Bianca Weinstock-Guttman
Institutions
- Isfahan University of Medical Sciences (IR)
- Jacobs Institute (US)
- Shahid Beheshti University of Medical Sciences (IR)
- University at Buffalo, State University of New York (US)
Publication Details
- Journal
- PLoS ONE
- Published
- 2026-03-20
- DOI
- https://doi.org/10.1371/journal.pone.0344558
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00