B4GALT1 deficiency attenuates steatohepatitis by regulating the PPARγ/ACSL4 axis
Our findings suggest that B4GALT1 plays a crucial role in MASLD progression by targeting lipid peroxidation in hepatocytes via the PPARγ/ACSL4 axis, thus highlighting a potential therapeutic target for MASLD.
Authors
- Linfeng Wu (ORCID: https://orcid.org/0000-0003-0036-0455)
- Tao Chen (ORCID: https://orcid.org/0000-0001-9704-9545)
- Youjung Chien
- Xiaoqing Zeng (ORCID: https://orcid.org/0000-0003-3952-1076)
- Yingjie Ai
- Ruiqi Xia
- Da Zhou
Institutions
- Sun Yat-sen University (CN)
- Fudan University (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Fuzhou University (CN)
Publication Details
- Journal
- Hepatology Communications
- Published
- 2026-03-20
- DOI
- https://doi.org/10.1097/hc9.0000000000000920
- Primary Topic
- Peroxisome Proliferator-Activated Receptors
- Type
- article
- Field-Weighted Citation Impact
- 0.00