The Wnt receptor Frizzled3 (FZD3) drives aggressive phenotypes in small cell lung cancer

FZD3 is frequently overexpressed in SCLC and serves as an independent prognostic indicator for poor survival. Our findings elucidate the oncogenic role of FZD3 in SCLC, highlighting its potential as a therapeutic target and prognostic biomarker.

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Publication Details

Journal
Respiratory Research
Published
2026-03-21
DOI
https://doi.org/10.1186/s12931-026-03634-1
Primary Topic
Lung Cancer Research Studies
Type
article
Field-Weighted Citation Impact
0.00
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article

The Wnt receptor Frizzled3 (FZD3) drives aggressive phenotypes in small cell lung cancer

Jinghong Wu, Zhendong Qin, Tongmei Zhang, Mingjun Lu et al.
Respiratory Research
Lung Cancer Research Studies
article

The Wnt receptor Frizzled3 (FZD3) drives aggressive phenotypes in small cell lung cancer

Jinghong Wu, Zhendong Qin, Tongmei Zhang, Mingjun Lu, Jiabao Hou, Jiaqi Zhao, Dongchang Wang, Xiaoyue Zhu, Xiaoqing Cao, Teng Ma, Chenyang Wang, Jingwei Guo
article en

Abstract

FZD3 is frequently overexpressed in SCLC and serves as an independent prognostic indicator for poor survival. Our findings elucidate the oncogenic role of FZD3 in SCLC, highlighting its potential as a therapeutic target and prognostic biomarker.

Respiratory Research
Capital Medical University (CN), Beijing Chest Hospital (CN)
No poverty
Openalex Percentile: Top 14%
Lung Cancer Research Studies
DOIOpen Access PDFOpenAlex
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