Graves Hastalığı ve Multinodüler Guatr Zemininde Gelişen Klasik Varyant Papiller Tiroid Karsinomu: Eğilim Skoru Eşleştirilmiş Karşılaştırma

ABSTRACTObjective: There are conflicting data in the literature regarding the prognosis and aggressiveness of papillary thyroid carcinoma arising in the background of Graves’ disease. This study aimed to compare the histopathologic features of incidentally discovered classic variant papillary thyroid carcinomas in Graves’ disease and multinodular goiter backgrounds using propensity score matching.Material and Methods: Patients who underwent total thyroidectomy for benign indications and were found to have classic variant papillary thyroid carcinoma on histopathologic examination at Çukurova University Balcalı Hospital between 2015 and 2025 were retrospectively evaluated. Graves’ disease diagnosis was established based on the criteria of at least 2 years of antithyroid drug use, TSH receptor antibody positivity, and presence of clinical/radiologic ophthalmopathy. Groups were balanced by propensity score matching at a 1:3 ratio for age and sex. Histopathologic aggressiveness parameters were compared using non-parametric tests.Results: A total of 44 patients with incidentally discovered classic variant papillary thyroid carcinoma following thyroidectomy for benign indications were categorized into Graves’ disease (n=11) and multinodular goiter (n=33) groups.After matching, standardized mean difference of