CONCEPTUAL STUDY OF DOOSHI VISHA AND ITS CORRELATION WITH ALLERGIC SKIN DISEASES: A COMPREHENSIVE REVIEW

Background: Dooshi Visha, described in Ayurvedic classics as cumulative low-potency toxins from Viruddha Ahara, Agnimandya, and environmental factors, correlates with chronic allergic skin disorders like urticaria and eczema by disrupting Rakta Dhatu and immunity. Objective: This review examines the conceptual framework of Dooshi Visha and its pathogenesis in relation to allergic skin manifestations, integrating Ayurvedic and modern immunological perspectives. Methods: Comprehensive analysis of classical texts (Charaka, Sushruta) and contemporary literature on Dooshi Visha's role in hypersensitivity reactions, including Nija/Bahya Gara Visha effects on Twak Vikara. Results: Dooshi Visha induces Kapha-Pitta vitiation, Ojas kshaya, and IgE-mediated inflammation, manifesting as edema, pruritus, and dermatitis; parallels modern allergen-induced mast cell degranulation. Conclusion: Shodhana and Shamana therapies offer holistic detoxification, bridging Ayurveda with allergen avoidance strategies. Empirical validation is recommended for clinical application.