A Case Report of Feline Cholangiohepatitis: Clinical Presentation and Diagnostic Work-Up

An 8-year-old male Maine Coon cat weighing 4.1 kgs presented with jaundice and constipation for over one week. The chief complaint included lethargy, anorexia, and reduced water intake. A veterinarian had previously administered glycerin and bisacodyl enemas, but complete evacuation of the stool was not achieved. Hematological and serum biochemical analyses revealed non-regenerative anemia, lymphocytopenia, neutrophilia, and eosinopenia. Liver function tests showed elevated alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), total bilirubin, bile acids, and amylase levels. Abdominal ultrasonography demonstrated a markedly enlarged gallbladder with a thickened wall and a slightly hyperechoic intraluminal mass suggestive of sludge. Furthermore, dilatation of the hepatic artery and portal vein was observed, consistent with hepatic inflammation. Based on the clinical presentation, hematological and biochemical profiles, and ultrasonographic findings, cholangiohepatitis was diagnosed with a guarded to poor prognosis (dubia ad infausta). Intravenous fluid therapy, a hepatic-support diet, and hepatoprotective medication were all part of the therapeutic strategy to promote liver function. Close observation of liver enzyme levels and the patient’s reaction to treatment will be crucial in addition to these measures. This case report presents the diagnostic work-up to feline cholangiohepatitis identified through the clinical manifestation of jaundice.