ANTI-MÜLLERIAN HORMONE AS A BIOMARKER OF FERTILITY IN WOMEN DIAGNOSED WITH POLYCYSTIC OVARY SYNDROME

PCOS is the most common hormonal disorder and cause of infertility in females of reproductive age. The symptoms and their severity vary strongly between particular cases. PCOS is correlated with hormonal, environmental and genetic factors. Complex interactions between genetics and hormonal levels is important to understand the hormonal 31 abnormality and to assess the chance of pregnancy in women with PCOS. The research was conducted on patients in the age of 27 ± 5 years treated in the 33 Gynecology and Oncology Clinic of CMUJ. The research group-PCOS patients (P) n=62. The control group(C) n=45. The venous blood was collected in volume of 2 ml centrifuged for 15 min at 1400 rpm. Serum was aspirated to 1.5 ml Eppendorf tubes. The ELISA method was used. The statistical analysis revealed significant differences in the level of selected factors 38 between the two groups at p<0.01. FSH (U/ml): P 5,10 (± 1,64) vs K 8,96 (± 6,15) LH (IU/ml): P 8,59 (± 6,79) vs K 11,0 (± 6,15) AMH [ng/ml]: P 4,06 (± 2,43) vs K 1,47 (± 2,14). AMH levels in the PCOS group did not show a significant difference in correlation with age. Obese and overweight women in both 42 groups had significantly different levels of AMH compared with normal-weight women. Furthermore, AMH levels were positively correlated with the age of the first period in the PCOS. The studies indicate a high use of the hormones like FSH and AMH in the diagnosis and assessment of ovarian reserve in women with PCOS.