Domain-weighted Block Coordinate Descent for quantitative single-sided MPI reconstruction

Single-sided Magnetic Particle Imaging (MPI) provides a solution suitable for intraoperative localization. However, asymmetric coil arrangements cause nonuniform magnetic fields and depth-dependent sensitivity decay, leading to biased reconstructions. This paper proposes a domain-weighted Block Coordinate Descent (DW-BCD) algorithm for quantitative single-sided MPI reconstruction. A preliminary reconstruction estimates the signal support domain, from which weighting and regional partitioning are derived. The subsequent reconstruction combines block-wise domain-weighted and global total variation(TV) regularization. Experiments show that DW-BCD effectively reduces depth-related concentration bias, enabling accurate quantitative reconstruction of magnetic nanoparticle distributions for clinical applications of single-sided MPI.