Spatially Distinct Myosin II Architectures Regulate Protrusion Dynamics and Directional Persistence during Immune Cell Migration
Migrating neutrophils assemble spatially distinct myosin II architectures at the leading edge and rearProtrusion dynamics and directional persistence are linked to sustained myosin II engagementDirectional migration emerges from the temporal organization of protrusion states rather than their abundance.
Authors
- Nicolas Mélis (ORCID: https://orcid.org/0000-0001-7456-6232)
- Bhagawat C. Subramanian (ORCID: https://orcid.org/0000-0002-6976-7512)
- Desu Chen (ORCID: https://orcid.org/0000-0003-4255-0361)
- Wolfgang Losert (ORCID: https://orcid.org/0000-0002-1792-7860)
- Yeap Ng (ORCID: https://orcid.org/0000-0002-5702-8296)
- Roberto Weigert (ORCID: https://orcid.org/0000-0003-0740-4465)
- Thomas D. Madsen (ORCID: https://orcid.org/0000-0002-7598-4636)
- Emily Chen (ORCID: https://orcid.org/0000-0002-3669-0846)
- Weiye Wang
- Carole Parent
Institutions
- Inserm (FR)
- University of Michigan (US)
- Université de Poitiers (FR)
- National Cancer Institute (US)
- Center for Cancer Research (US)
- University of Maryland, College Park (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-03-16
- DOI
- https://doi.org/10.64898/2026.03.13.711384
- Primary Topic
- Cellular Mechanics and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00