Integrating snRNA-seq and gene perturbation reveals regulatory networks of intramuscular fat deposition in bovine skeletal muscle
Our findings establish VEndoCs as active regulators of intramuscular adipogenesis via a BMPR1A-mediated signaling pathway. These results provide new insights into the cellular and molecular basis of marbling in cattle and highlight BMPR1A as a potential target for genetic or nutritional strategies aimed at improving meat quality.
Authors
- Guiting Han
- Yanchun Bao (ORCID: https://orcid.org/0000-0002-6102-5098)
- Risu Na (ORCID: https://orcid.org/0000-0001-8965-6054)
- Caixia Shi
- Jiaxin Zhang (ORCID: https://orcid.org/0000-0003-3827-8422)
- Yaqiang Guo
- Mingjuan Gu
- Wenguang Zhang
- Le Zhou
- Shuai Li
- Fengying Ma
- Chencheng Chang
- Lin Zhu
Institutions
- Inner Mongolia Agricultural University (CN)
Publication Details
- Journal
- Animal Bioscience
- Published
- 2026-03-11
- DOI
- https://doi.org/10.5713/ab.250897
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00